Mesothelioma: Treatment Options for an Incurable Disease

Mesothelioma is a rare and aggressive form of cancer. In most cases, the prognosis is very poor at the time of diagnosis. Generally, patients are not more than twelve months to live after a positive diagnosis of mesothelioma. Thus, the treatment options for such an aggressive and rapidly developing disease are quite limited. Mesothelioma treatment is usually palliative. In other words, the goal of treatment is to simply rid the patient of pain symptoms associated with mesothelioma. There is no hope of treatment of patients from the disease for several reasons:

(i) diagnosis occurs very late in the disease. By the time a diagnosis is made there is no hope for the patient.

(ii) development of the disease is very fast and affects critical organs like the heart and lungs.

surgery

or cytoreduction surgery involves removing all or nearly all the visible tumor. In the case of mesothelioma, usually in combination with chemotherapy to more effectively remove cancer cells. Some surgical operations aimed at treating a patient, especially if the cancer is still localized. In most other cases, surgery May only have a palliative effect as the cancerous mass smanjuje.Sljedeće types of surgery used to treat mesothelioma:

(i) pleurodesis: inserting an irritant into the pleural space causing inflammation, which closes down the pleural space, thereby inhibiting fluid accumulation (pleural effusion). Most of the symptoms associated with pleural mesothelioma can be cured with this method for a vrijeme.Thoracoscope used to it.

(ii) or Pleurectomy peritonectomy: removal of part of the chest or abdomen lining trim (depending on where the cancer ).

(iii) Decortication:. Removing all or part of the membrane covering the organs

(iv) pneumonectomy: removal of the entire affected lung (in most cases, mesothelioma develops in only one lung, so that the removal of the lung can be cured if the patient's cancer has not spread ).

Chemotherapy

Chemotherapy involves the administration of drugs that destroy cancer cells. Chemotherapy in the treatment of mesothelioma may have the following goals:

(i) Shrinkage of the tumor before surgery (neo-adjuvant chemotherapy ).

(ii) the destruction of cancer cells after surgery (adjuvant chemotherapy ).

(iii) increase the effectiveness of radiation therapy (immunotherapy ).

Chemotherapy is used in cases where cancer cells have spread beyond the initial page appears. It is also used, where the patient is a candidate for surgery.

The most commonly used drug for mesothelioma is pemetrexed, which is an inhibitor of many proteins that are required for DNA synthesis and cell replication.

Chemotherapy has different side effects because in the process of destroying cancer cells healthy cells are also damaged.

Radiotherapy

This refers to the treatment of cancer using penetrating beams of high energy. In the case of mesothelioma, radiotherapy can be used in combination with surgery in an attempt to cure or control your weight simptoma.Primjer radiotherapy is intensity-modulated radiotherapy (IMRT) that uses a computer generated image of the target cancer cells directly from a limited impact on the surrounding tissue.

Mesothelioma and New Comprehensive Approach of Cytoreductive Surgery

Another interesting study entitled "Abdominal computed tomography scans in the selection of patients with malignant peritoneal mesothelioma for comprehensive treatment with cytoreductive surgery and perioperative intraperitoneal chemotherapy" by
. Tristan D. Yan MD, NAMIC Haverić Dr. Carlos P. Carmignani Dr. David Chang MS, Paul H. Sugarbaker, MD - Cancer Volume 103, Number 4, pages 839-849, 15 February 2005 Here's an excerpt: "Summary - Background - Malignant peritoneal mesothelioma is a rare and fatal disease, until recently, treatment options were very limited and ineffective new comprehensive approach to cytoreductive surgery with perioperative intraperitoneal chemotherapy has improved survival rates for the cost of considerable morbidity and mortality as .. in other peritoneal surface malignancies. the outcome after these treatments is mainly dependent on adequate cytoreduction. The aim of this study was to determine the computed tomography (CT) scan images that are useful in patient selection for this comprehensive approach.

methods - Analysis of preoperative CT of 30 patients with peritoneal mesothelioma treated with cytoreductive surgery and perioperative intraperitoneal chemotherapy in one institution was performed. Based on the size of the tumor nodules remaining after cytoreductive surgery, patients were divided into 2 groups: those with residual lesions ≤ 2.5 cm (corresponding cytoreduction) and those with the rest of the lesions> 2.5 cm (suboptimal cytoreduction). CT for each patient were evaluated by a standardized scoring system with a copious reader operative findings. Thirty-nine CT parameters were obtained and statistically analyzed to determine their association with variables, test results, or adequacy of cytoreduction.

RESULTS - Seven patients (64%) in suboptimal cytoreduction group and 2 patients (11%) in the corresponding cytoreduction group had a> 5-cm tumor mass in the epigastric region (P = 0.004). Nine patients (82%) in group 2 patients and suboptimal (11%) in the corresponding groups of cytoreduction is the CT scan which showed a loss of normal architecture of the small bowel and mesentery (P <0.001). In a complex analysis of the two radiological features, none of the patients with> 5-cm tumor mass in the epigastric region and loss of normal architecture of the small intestine and mesentery had an adequate cytoreduction. Patients who did not have these two preoperative CT findings of a 94% probability of adequate cytoreduction.

CONCLUSIONS - CT effectively identified a peritoneal mesothelioma tumor at key anatomical sites. Because adequate cytoreduction is necessary to achieve prolonged survival, CT has become an accurate prognostic radiologic test for patient selection for comprehensive treatment.

CONCLUSIONS - CT effectively identified a peritoneal mesothelioma tumor at key anatomical sites. Because adequate cytoreduction is necessary to achieve prolonged survival, CT has become an accurate prognostic radiologic test for patient selection for comprehensive treatment.

Another interesting study called "anti-tumor activity of K1-LysPE38QQR, Immunotoxin targeting mesothelin, Cell-surface antigen expressed in ovarian cancer and malignant mesothelioma" by Hassan, Raffit, Viner, Jaye L Wang, Qing-Cheng, Margulies, Inger, Kreitman, Robert J, Pastan, Ira - Journal Immunotherapy:
. July / August 2000 - Volume 23 - Issue 4 - pp 473-479 Here is an excerpt: "Abstract - mesothelin, a differentiation antigen, is a 40 KD glycosylphosphatidylinositol-linked cell surface glycoprotein that is present on the surface of normal mesothelium and is expressed in many patients with epithelial ovarian cancer and malignant mesotheliomas. monoclonal antibody K1 is a murine immunoglobulin G1 that recognizes mesothelin. LysPE38QQR the truncated form of Pseudomonas Exotoxin no cell binding domain, but retains the expulsion and adenosine diphosphate-ribosylation domain. This is a lysine residue near the amino end of the available for conjugation to antibodies. to prevent chemical conjugation of antibody to lysine residues in the C-terminus of Pseudomonas Exotoxin, two lysine residues at positions 590 and 606 were mutated to glutamine, lysine and the rest at position 613 was mutated to arginine. monoclonal antibody K1 was chemically conjugated with LysPE38QQR, modifying the antibody with sulfo-succinimidyl-4-(N-maleimidomethyl) cyclohexane-1-carboxylate and coupling with SPDP N-succinimidyl 3 -. (2-pyridyldithio) propionate-modified LysPE38QQR result immunotoxin K1-LysPE38QQR is highly toxic to A431-K5 cells (human epidermoid carcinoma cell line transfected with a mesothelin expression plasmid) with half-maximal inhibitory concentration of 3-6 ng / ml. immunotoxin has negligible activity against A431 cells, which do not express mesothelin (median inhibitory concentration> 100 ng / mL). This immunotoxin also caused complete regression of tumors in nude mice that received xenografts of mesothelin-positive human cancers. These results show that immunotoxins directed against mesothelin are a therapeutic option that deserves further investigation for the treatment of ovarian cancer and malignant mesotheliomas. "

Tips to Find Mesothelioma Attorney

people who are suffering from Mesothelioma needs legal support for getting compensation. There are many attorneys out there who can help victims obtain compensation from asbestos manufacturers. Today you can easily find specialized mesothelioma attorneys. They have a lot of knowledge and experience in this field.

There are many things that a lawyer can do for the patient and his family. Advocates can help victims not only in recovering medical expenses, and lost wages and punitive fees. It's a good idea to spend some time with a lawyer before you decide anything. The victim needs to share all your fears and expectations with a company representative.

company providing legal support for the patient has to do with medical and legal associations. You should always look for a company that has a good reputation and experience.

Do you know enough about Mesothelioma? This is one of the most devastating forms of cancer. It is mainly found in people exposed to asbestos particles for a long time. Asbestos particles are very harmful to the organ systems of the human body.

There are two main types of this form raka.Prvi called benign, and the other is malignant. The malignant form is seen more uobičajeno.Najčešći form of the disease is diffuse malignant pleural mesothelioma. Malignant form of the disease spreads rapidly and can reach other organs and systems such as the heart and gastrointestinal tract.

malignant form is not curable and life expectancy of patients diagnosed with mesothelioma it is very manje.Pacijent can live several years if timely diagnosis is made. It's a good idea to visit a doctor about the onset of symptoms. A person suffering from this form of the disease in need of professional care and emotional support.

If your loved one has been diagnosed with mesothelioma then I would recommend you to look for a proper medical and legal support.

There are many law firms that specialize in asbestos cancer. You should try your best to find an experienced and reputed lawyer. You can find a lawyer using the yellow pages, online directories and related websites. It's a good idea to consult friends or relatives who have recently used the case of asbestos cancer.

Finding a Legal Aid is a little difficult, but it can easily be done if you follow some tips and instructions that are mentioned in this article.

Was ist Peritoneal-Mesotheliom, und was können wir dagegen tun?

Peritoneal-Mesotheliom ist eine schreckliche Krankheit, die empfindlichen Zellen als Ganzes, bilden die innere Auskleidung der Bauchhöhle Schäden. Wie wir alle wissen, ist die Bauchhöhle ein sehr wichtiger Teil der Körperorgane. Es ist sehr wichtig, denn es schützt einige der zarteren Organe des Körpers, wie zum Beispiel die Lunge ein Paar.

Im Allgemeinen ist die Innenwand der Bauchhöhle besteht aus zwei Membranen besteht, und dass die viszerale und parietale Membranen. So diese Menschen, die Asbest einatmen in irgendeiner Weise geschehen würde, wird von Mikroorganismen in den Körper gelangen und kann leicht dazu, die die Zellen der inneren Wand der Bauchhöhle. Als Ergebnis, Inhalation, und im Laufe der Zeit hat sich die Bauchhöhle und endet oštećenja.Dijagnoza Peritoneal-Mesotheliom tatsächlich wie folgt zustande.

Nach dem Asbest in den Körper eingeatmet wird, wird es die Struktur der Zellen, die in der viszeralen und parietalen Schicht eingebettet sind, zu beginnen, im Laufe der Zeit ändern verursachen. Zunächst teilen Zellen und als Ergebnis dieser Division, landen sie zadebljanja.Eventualne Verdickung der Zelle einen Wert von Schichten, um Tumore zu machen können, und dies wird den Organen, die durch die Bauchhöhle zu langsam Zusammenbruch des Tages geschützt sind Ursache. Als weiteres Ergebnis auftritt, kann die Leber im Laufe der Zeit beschädigt werden.

, aber in der heutigen Zeit, sind Ärzte in der Regel nicht in der Lage, die Früherkennung. Dies liegt daran, CT durchgeführt wird, leider kann man nicht einfach zeigen die Schäden an der Bauchhöhle in frühen Stadium der Erkrankung. Obwohl die Krankheit zu einem späteren Zeitpunkt sein kann, in einer kleinen Gruppe von Tumoren, oder sogar ein Tumor entstehen. Als Folge des Tumors zu halten zunehmend in der Größe im Laufe der Zeit können sie dann durch CT-Scans erkannt werden und eine Diagnose der Krankheiten und zum Glück, und dann eine geeignete Behandlung beginnen kann und die Heilungschancen hoffen wir, zu erhöhen.